AxoSim partners with preclinical scientists to solve advanced problems
For toxicologists and discovery scientists, we help you move from your high-throughput, in-vitro assays to make the most informed decisions moving all the way to IND-enabling studies. AxoSim’s SimLab provides services to help in several stages of your development funnel.
Drug formulation candidate selection is difficult and imperfect. Selecting the wrong candidate can lead to astronomical amounts of money, time, and resources wasted.
AxoSim is dedicated to working with our clients to identify better candidates, earlier and more accurately in the funnel.
We will be your partner in advancing your drug development programs.
In a 2D environment
Need to learn more about your drug candidates’ target activity through advanced neuronal co-culture models? Our team of neuroscientists and biomedical engineers use state of the art cell culture methods and technology to answer your hypotheses faster.
Microelectrode Array (MEA)
Characterize functional differences in neuronal activity and network characteristics. Outputs include: firing rate, burst rate, burst duration, interburst interval, and network synchronization.
High-Content Screening (HCS)
Explore changes in neurite outgrowth, cell viability, and receptor and protein expression. Metrics include: neurite length, neurite branching, cell density, live/dead, and percent expression.
In a 3d Environment
Need to explore mechanism of action to select a better candidate to progress into in vivo studies? Our Nerve-on-a-Chip is the only model in the industry to provide the exact same metrics used by clinicians to diagnose and track disease progression, nerve conduction velocity and histomorphometry, to give you clinically predictive data faster, helping to take the guessing game out of candidate selection.
Understand mechanism of action by correlating functional nerve conduction measurements (NCV) and structural histomorphometry.
Study patient derived and genetically modified co-culture models of neurodegenerative diseases where electrical and structural pathology are critical.
Custom Human Model
Have you had a clinical candidate show different results across species? Use our human model to make the case for why the accuracy of your candidate should be trusted from a mechanism of action perspective.